Mouse eggs created from stem cells for the first time

By Jessica Hamzelou
NewScientists – The use eggs can now be cooked up from scratch. Using stem cells, a Japanese team has created healthy eggs that, once fertilised, grow into normal mouse pups.

Both egg and sperm cells start life as primordial germ cells (PGCs). Last year, Katsuhiko Hayashi and his colleagues at Kyoto University in Japan found they could generate PGC-like cells from either mouse embryonic stem cells or body cells that can turn into stem cells – known as induced pluripotent stem cells or IPSCs. What’s more, the team managed to coax these PGC-like cells into becoming sperm (Cell, DOI: 10.1016/j.cell.2011.06.052).

Now Hayashi and his colleagues have created eggs from the PGC-like cells. They started with embryonic stem cells and IPSCs taken from a female mouse embryo. In separate experiments, the team coaxed each type of stem cell to form PGC-like cells. When these cells were surrounded by ovary cells, also taken from a mouse embryo, they formed immature egg cells. … >>Continue<<

Source and Photo: NewScientist, October 4th, 2012
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2 responses to “Mouse eggs created from stem cells for the first time

  1. Hello. impressive job. I did not imagine this. This is a remarkable story. Thanks! PoIuYt

  2. Wow. This page is great! Thanks a lot!

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