Avisite – The researchers Arthur Gruber and Alda Wood, teachers of the Institute of Biomedical Sciences, USP, and his research group have innovated. While most research groups in Eimeria, the causative agent of avian coccidiosis, has worked with the intracellular parasite stages, those that are present in the host, the USP group identified the existence of another important stage that is also necessary to know: the oocyst.
Arthur explains: “The oocyst released in the feces of birds with coccidiosis is not able to infect others. For this, he must suffer the environment a process called sporulation, which depends on adequate conditions of oxygenation, moisture and temperature. ”
From the data generated will be possible to identify what these genes and their possible functions. “This knowledge can help us develop new methods of coccidiosis control in the environment, in order to inhibit sporulation and therefore reducing the infective load of a chicken shed,” said Arthur. The study was conducted entirely in Brazil, involving a multidisciplinary team that includes veterinarians, biologists and researchers in the field of computing. The bioinformatics was instrumental in the group could perform the analysis of thousands of gene sequences and integrate the results.
Part of the computational tools necessary for analyzing of thousands of sequences was carried out by the group. And, this work resulted in a further innovation: the creation of a platform called EGene analysis, which allows you to process the raw data sequences, integrate them and characterize them as to the biological functions performed by their genes, a task called “functional annotation”. Arthur Gruber says that, besides contributing to the study of genes of Eimeria, the EGene’s program was published in the scientific literature and is available for free on the Internet, thus allowing other researchers can use it in their research.
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